FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis
Keywords:
macular amyloidosis, lichen amyloidosis, FotoFinder dermoscopy, white rosettesAbstract
Background: Primary localized cutaneous amyloidosis (PLCA) causes extracellular proteinaceous deposits in skin. It is clinically divided into macular amyloidosis, lichen amyloidosis and nodular amyloidosis. Atypical presentations of PLCA make the diagnosis challenging, requiring biopsy to confirm amyloid deposition in the upper papillary dermis.
Objectives: This study used FotoFinder dermoscopy to characterize lichen and macular amyloidosis and correlated the dermoscopic features with histopathological findings.
Methods: This cross-sectional study enrolled patients with a clinical and histopathological diagnosis of PLCA. Dermoscopic examination was performed using the FotoFinder dermoscope, which provides a range of magnification from 20´ to 140´.
Results: A total of 30 patients were included in the study. Common dermoscopic patterns of MA were white or brown central hubs, and common patterns of LA were white structureless, scar-like areas and central hubs. New dermoscopic findings were a day lily appearance in MA and white rosettes in LA.
Conclusions: Dermoscopy plays a pivotal role in demonstrating characteristic findings of PLCA. These findings were well corelated with histopathology, thus avoiding unnecessary biopsy for arriving at an accurate diagnosis of PLCA.
References
Li WM. Histopathology of primary cutaneous amyloidoses and systemic amyloidosis. Clin Dermatol. 1990;8:30-35. DOI: 10.1016/0738-081x(90)90085-f. PMID: 2224734.
Tan T. Epidemiology of primary cutaneous amyloidoses in southeast Asia. Clin Dermatol. 1990;8:20–24. DOI: 10.1016/0738-081x(90)90083-d. PMID: 2224732.
Padhiar B, Karia U, Shah B. Primary cutaneous amyloidosis. Indian J Dermatol Venereol Leprol. 1997;63:105-106.
Nischal KC, Khopkar U. Dermoscope. Indian J Dermatol Venereol Leprol. 2005;71:300-303. DOI: 10.4103/0378-6323.16633. PMID: 16394450.
Nirmal B. Dermatoscopy: physics and principles. Indian J Dermatopathol Diagn Dermatol. 2017;4:27-30. DOI: 10.4103/ijdpdd.ijdpdd_13_17.
Wei-Min Li MB. Histopathology of primary cutaneous amyloidosis and systemic amyloidosis. Clin Dermatol. 1990;8:30-5. DOI: 10.1016/0738-081x(90)90085-f. PMID: 2224734.
Salim T, Shenoi SD, Balachandran C, Mehta VR. Lichen amyloidosus: A study of clinical, histopathologic and immunological findings in 30 cases. Indian J Dermatol Venerol Leprol. 2005;71:166-9. DOI: 10.4103/0378-6323.16230. PMID: 16394404.
Chuang YY, Lee DD, Lin CS, et al. Characteristic dermoscopic features of primary cutaneous amyloidosis: a study of 35 cases. Br J Dermatol. 2012;167(3):548-554. DOI: 10.1111/j.1365-2133.2012.11066.x. PMID: 22632408.
Maize J, Maize Jr J, Metcalf J. Metabolic diseases of the skin. In: Elder DE, Elenitsas R, Johnson BL, Murphy GF, eds. Lever’s Histopathology of the Skin. 9th ed. Philadelphia: Lippincott Williams and Wilkins; 2004:436-441.
Liebman TN, Rabinovitz HS, Dusza SW, Marghoob AA. Rosettes may be observed in a range of conditions. Arch Dermatol. 2011;147:1468. DOI: 10.1001/archdermatol.2011.312. PMID: 22184782
Ankad BS, Shah SD, Adya KA. White rosettes in discoid lupus erythematosus: a new dermoscopic observation. Dermatol Pract Concept. 2017;7(4):9-11. DOI: 10.5826/dpc.0704a03. PMID: 29214102.
Haspeslagh M, Noe M, De Wispelaere I, et al. Rosettes and other white shiny structures in polarized dermoscopy: histological correlate and optical explanation. J Eur Acad Dermatol Venereol. 2016;30(2):311-313. DOI: 10.1111/jdv.13080. PMID: 25786770.
Published
Issue
Section
License
Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.
How to Cite
Share
