Reflectance confocal microscopy of mammary Paget disease

Reflectance confocal microscopy of mammary Paget disease

Authors

  • Fezal Ozdemir Department of Dermatology and Venereology, Ege University Medical Faculty, Izmir, Turkey
  • Bengu Gerceker Turk Department of Dermatology and Venereology, Ege University Medical Faculty, Izmir, Turkey
  • Banu Yaman Department of Pathology, Ege University Medical Faculty, Izmir, Turkey
  • Giovanni Pellacani Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
  • Necmettin Ozdemir Department of Dermatology and Venereology, Ege University Medical Faculty, Izmir, Turkey
  • Isil Karaarslan Department of Dermatology and Venereology, Ege University Medical Faculty, Izmir, Turkey
  • Francesca Farnetani Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy

Keywords:

Paget disease, reflectance confocal microscopy, mammary

Abstract

Mammary Paget disease is the intraepidermal adenocarcinoma of the nipple area which is characterized usually by a well-demarcated eczematous plaque. Reflectance confocal microscopy (RCM), is an in vivo noninvasive diagnostic tool with a high-resolution imaging of the skin, almost comparable to conventional histology. RCM findings of Paget disease are limited in the literature. Most of the reported cases are the extramammary type. In this report, we aimed to evaluate the RCM findings of a non-pigmented mammary Paget disease in a 65 year-old woman.  

References

References:

Longo C, Fantini F, Cesinaro AM, Bassoli S, Seidenari S, Pellacani G. Pigmented mammary Paget disease: dermoscopic, in vivo reflectance-mode confocal microscopic, and immunohistochemical study of a case. Arch Dermatol. 2007;143(6):752-4.

Richtig E, Ahlgrimm-Siess V, Arzberger E, Hofmann-Wellenhof R. Non invasive differentiation between mamillary eczema and Paget disease by in vivoreflectance confocal microscopy on the basis of two case reports. Br J Dermatol. 2011;165(2):440-1

Pan ZY, Liang J, Zhang QA, Lin JR, Zheng ZZ. Invivo reflectance confocal microscopy of extramammary Paget disease: diagnostic evaluation and surgical management. J Am Acad Dermatol. 2012 ;66(2):e47-53.

Guitera P, Scolyer RA, Gill M, Akita H, Arima M, Yokoyama Y, Matsunaga K, Longo C, Bassoli S, Bencini PL, Giannotti R, Pellacani G, Alessi-Fox C, DalrympleC. Reflectance confocal microscopy for diagnosis of mammary and extramammary Paget's disease. J Eur Acad Dermatol Venereol. 2013;27(1):e24-9.

Cinotti E, Perrot JL, Labeille B, Cambazard F; Groupe imagerie cutanée non invasive de la Société française de dermatologie [The contribution of reflectance confocal microscopy in the diagnosis of Paget's disease of the breast]. Ann Dermatol Venereol. 2013 ;140(12):829-32.

Debarbieux S, Dalle S, Depaepe L, Jeanniot PY, Poulalhon N, Thomas L. Extramammary Paget's disease of the scalp: examination by in vivo and ex vivoreflectance confocal microscopy. Skin Res Technol. 2014;20(1):124-6.

Suppa M, Marneffe A, Miyamoto M, Rorive S, Boone M, Del Marmol V. Contribution of reflectance confocal microscopy in the diagnosis of extra-mammary Paget’s disease. Ann Dermatol Venerel. 2015; 142(1): 70-3.

Oliveira A, Zalaudek I, Arzberger E, Massone C, Hofmann-Wellenhof R. Reflectance Confocal Microscopy for Diagnosis of Mammary Paget's Disease. Acta Derm Venereol. 2016;96(7):980-982.

Braga JC, Scope A, Klaz I, Mecca P, González S, Rabinovitz H, Marghoob AA. The significance of reflectance confocal microscopy in the assessment of solitary pink skin lesions. J Am Acad Dermatol. 2009; 61(2):230-41.

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Published

2017-10-31

Issue

Section

Observation

How to Cite

1.
Ozdemir F, Gerceker Turk B, Yaman B, et al. Reflectance confocal microscopy of mammary Paget disease. Dermatol Pract Concept. 2017;7(4):75-80. doi:10.5826/dpc.0704a15

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