Association between melanocytic neoplasms and seborrheic keratosis: more than a coincidental collision?

Association between melanocytic neoplasms and seborrheic keratosis: more than a coincidental collision?

Authors

  • Jennifer DeFazio Dermatology Service, Memorial Sloan-Kettering Cancer Center, Hauppauge, NY, USA
  • Iris Zalaudek Division of Dermatology, Medical University of Graz, Graz, Austria & Dermatology Unit, 1st Medical Department, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
  • Klaus J. Busam Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY USA
  • Carlo Cota Dermatopathology Unit, San Gallicano Dermatological Institute, Rome, Italy
  • Ashfaq Marghoob Dermatology Service, Memorial Sloan-Kettering Cancer Center, Hauppauge, NY, USA

Keywords:

seborrheic keratosis, melanocytes nevus, cell-signalling, melanocytes, keratinocytes

Abstract

Clinical observations and an expanding knowledge of cell-to-cell communication have led us to speculate that the finding of a melanocytic nevus in conjunction with a seborrheic keratosis is more than a coincidental collision of two lesions. Here we present five cases demonstrating dermoscopic features of both melanocytic lesions and seborrheic keratoses with corresponding histology. Four cases demonstrate dermoscopic features of a melanocytic nevus and seborrheic keratosis, and the final case a melanoma arising in association with a seborrheic keratosis.

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Published

2012-04-30

Issue

Section

Observation

How to Cite

1.
DeFazio J, Zalaudek I, Busam KJ, Cota C, Marghoob A. Association between melanocytic neoplasms and seborrheic keratosis: more than a coincidental collision?. Dermatol Pract Concept. Published online April 30, 2012:35-41. doi:10.5826/dpc.0202a09

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