Interleukin-13 Inhibitors in the Treatment of Atopic Dermatitis: The Role of Tralokinumab

Interleukin-13 Inhibitors in the Treatment of Atopic Dermatitis: The Role of Tralokinumab

Authors

  • Annunziata Dattola Department of Dermatology University of Rome “La Sapienza”, Rome, Italy
  • Martina Tolone Department of Health Sciences- Unit of Dermatology, Magna Graecia University, Catanzaro, Italy
  • Emanuele Amore Department of Dermatology University of Rome “La Sapienza”, Rome, Italy
  • Luigi Bennardo Department of Health Sciences- Unit of Dermatology, Magna Graecia University, Catanzaro, Italy
  • Simone Amato Department of Dermatology University of Rome “La Sapienza”, Rome, Italy
  • Teresa Grieco Department of Dermatology University of Rome “La Sapienza”, Rome, Italy
  • Antonio Giovanni Richetta Department of Dermatology University of Rome “La Sapienza”, Rome, Italy
  • Giovanni Pellacani Department of Dermatology University of Rome “La Sapienza”, Rome, Italy
  • Nevena Skroza Dermatology Unit ‘Daniele Innocenzi’, Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy
  • Steven Paul Nisticò Department of Dermatology University of Rome “La Sapienza”, Rome; Department of Health Sciences- Unit of Dermatology, Magna Graecia University, Catanzaro, Italy

Keywords:

atopic dermatitis, anti IL13, tralokinumab, biologic therapy

Abstract

Introduction: The advent of biotechnological drugs has significantly changed the management of atopic dermatitis (AD) and the approach to the moderate-to-severe form of this chronic relapsing disease.

Objectives: The aim of our review is to summarize the current literature on anti-interleukin (IL)-13 in atopic dermatitis.

Methods: A literature search was organized and a systematic review was performed to summarize the most recent evidence supporting the efficacy and safety of tralokinumab.

Results: Tralokinumab (anti-IL-13) 300 mg every 2 weeks subcutaneously has proven effective in several clinical trials in adults and adolescents with moderate to severe atopic dermatitis inadequately controlled with other topical or systemic therapies. Tralokinumab was found to be significantly superior in terms of efficacy in reducing IGA, EASI-75, NRS pruritus, and DLQI scale numbers. During follow-up, tralokinumab was well tolerated with limited severity of adverse events.

Conclusion: Tralokinumab leads to statistically significant improvements in disease severity and outcome scores. It represents an effective treatment option for adults with moderate to severe AD, but further large-scale studies are needed to verify long-term superiority over other treatments.

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Published

2024-07-31

How to Cite

1.
Interleukin-13 Inhibitors in the Treatment of Atopic Dermatitis: The Role of Tralokinumab. Dermatol Pract Concept [Internet]. 2024 Jul. 31 [cited 2024 Dec. 5];14(3):e2024204. Available from: https://www.dpcj.org/index.php/dpc/article/view/4315

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