Alterations of the human gut microbiome in patients with hidradenitis suppurativa: a case-control study and review of the literature: Gut microbiome in hidradenitis suppurativa

Neslihan Demirel Öğüt; Gülşen Hasçelik; Nilgün Atakan

doi:10.5826/dpc.1204a191

Alterations of the human gut microbiome in patients with hidradenitis suppurativa: a case-control study and review of the literature

Gut microbiome in hidradenitis suppurativa

Authors

Neslihan Demirel Öğüt Hacettepe University, Department of Dermatology and Venereology, Ankara, Turkey
Gülşen Hasçelik Hacettepe University, Department of Medical Microbiology, Ankara, Turkey
Nilgün Atakan Hacettepe University, Department of Dermatology and Venereology, Ankara, Turkey

Keywords:

hidradenitis suppurativa, inflammatory skin disorders, gut microbiome

Abstract

Background: Hidradenitis suppurativa (HS) is a systemic inflammatory disease that extends beyond the skin. The role of gut microbiome alterations in the pathogenesis of inflammatory and autoimmune disorders is remarkable.Objective: Based on the hypothesis that dysbiosis in the gut microbiome may be a trigger for systemic inflammation in the pathogenesis of HS, the aim of this study was to investigate whether the gut microbiome is altered in HS patients comparing with healthy subjects.Methods: In present case-control study, fecal samples from 15 patients with HS and 15 age- and sex-matched healthy individuals were collected and analyzed using 16S rRNA-based metagenomic analysis. The V3 and V4-hypervariable regions of 16S rDNA gene were amplified from all samples and sequenced by the Illumina MiSeq platform. Bioinformatic analyzes were performed in QIIME2. Results: Shannon alpha diversity index showed significantly reduced diversity in HS patients (P = 0.048). Bray-Curtis Dissimilarity and Jaccard Distance revealed that the gut microbial composition of HS patients was significantly distinctive from that of controls (P = 0.01 and P = 0.007, respectively). The relative abundance of unclassified Clostridiales, unclassified Firmicutes and Fusicatenibacter in HS was significantly lower than that in controls (P = 0.005, P = 0.029, and P = 0.046, respectively).Conclusion: This study indicated that significant alterations in gut microbiota of HS patients could play a critical role in the pathogenesis of HS and might be a trigger for systemic inflammation. Increased understanding the pathogenesis of HS will shed light on the new potential therapeutic targets and novel treatment options.

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