Evaluation of MCV/RDW Ratio and Correlations with Ferritin in Telogen Effluvium Patients
Evaluation of MCV/RDW Ratio in Telogen Effluvium
Keywords:
Telogen effluvium, ferritin, MCV/RDW, correlation, alopeciaAbstract
Objective: Telogen effluvium is one of the chronic diseases that affect the quality of life (QoL) in women. The study aimed to evaluate the RDW/MCV ratio and its correlation with ferritin in Telogen Effluvium patients and to reveal their potential role in the etiopathogenesis of Telogen effluvium.
Material and Methods: We retrospectively evaluated the medical data of 250 patients who were admitted to the dermatology outpatient clinic between September 2020 and December 2020 with a diagnosis of Telogen effluvium. The control group was created retrospectively from the medical records of 250 healthy individuals. HB, HCT, MPV, MCV, RDW, ferritin, and MCV/RDW ratio of both groups were compared and evaluated statistically.
Results: All of the Telogen effluvium patients were women in terms of gender. The mean age of the patient group was 33,11±9,66 years and the mean age of the control group was 34,98±12,37 years. The ratio of MCV/RDW, MPV, MCV, and ferritin is lower in the group with Telogen effluvium compared to the control group and a statistically significant difference was found(p<0.05). However, the correlation between MCV/RDW ratio and ferritin was evaluated in Telogen effluvium patients, and no significant differences were found (p>0.05).
Conclusion: Iron deficiency anemia is thought of as a factor in female patients with telogen effluvium. Although the data shows the correction of iron deficiency is insufficient telogen effluvium, we proposed that laboratory tests should be routinely used in the diagnosis and treatment phase of patients who apply with the complaint of hair loss.
References
Özden MG, Öztaş MO, Gülekon A, Gürer MA. Kadın olgularda yaygın saç kaybı ve eşlik eden bulgular. J Exp Clin Med 2008;25(2):50-6.
Obaidat NA, Rawashdeh BT, Wreikat A, Awamleh AA. A potential relation between telogen effluvium and iron deficiency in adult females. J Res Med Sci 2005;12(1):62-6.
Sinclair R. Diffuse hair loss. Int J Dermatol 1999;38(S1):8-18
Shrivastava SB. Diffuse hair loss in an adult female: approach to diagnosis and management. Indian J Dermatol Venereol Leprol 2009;75(1):20-7.
Akyurek FT, Demirbas GU, Demirbas A, Akyurek F, Kurtipek GS. Retrospective evaluation of laboratory data of patients with telogen effluvium. Ann Med Res 2019;26(12):2754-7.
Trost LB, Bergfeld WF, Calogeras E. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. J Am Acad Dermatol 2006;54(5):824-44.
Rushton D, Ramsay I, James K, Norris M, Gilkes J. Biochemical and trichological characterization of diffuse alopecia in women. Br J Dermatol 1990;123(2):187-97.
Trost LB, Bergfeld WF, Calogeras E. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. J Am Acad Dermatol 2006;54(5):824-44.
Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood 2003;101(9):3359-64.
Rushton DH, Norris MJ, Dover R, Busuttil N. Causes of hair loss and the developments in hair rejuvenation. Int J Cosmet Sci 2002;24(1):17-23.
Kantor J, Kessler LJ, Brooks DG, Cotsarelis G. Decreased serum ferritin is associated with alopecia in women. J Invest Dermatol 2003;121(5):985-8.
Güler Özden M, Öztaş MO, Gülekon A, Gürer MA. [Diffuse hair loss in females and associating findings]. OMÜ Tıp Dergisi 2008;25(2):50-6.
Sinclair R. Diffuse hair loss. Int J Dermatol 1999;38(Suppl 1):8-18.
Evans TC, Jehle D. The red blood cell distribution width. J Emerg Med 1991;9(1):71-4.
Bessman JD, Gilmer PR, Gardner FH. Improved classificationof anemias by MCV and RDW. Am J Clin Pathol 1983; 80:322-26.
Springer K, Brown M, Stulberg DL. Common hair loss disorders. Am Fam Physician 2003;68(1):93-102.
Bergfeld W. Diffuse hair loss: its triggers and management. Cleve Clin J Med 2009;76(6):361-70.
Malkud S. Telogen effluvium: a review. J Clin Diagn Res 2015;9(9):1-3.
Messenger AG, Berker DA, Sinclair RD. Disorders of hair In: Burns T, Breathnach S, Cox N, Griffiths C, eds. Rook’s text book of dermatology. 8 th ed. Oxford: Blackwell Publishing 2010:p.66-100.
Cheung EJ, Sink JR, English Iii JC. Vitamin and mineral deficiencies in patients with Telogen Effluvium: a retrospective cross-sectional study. J Drugs Dermatol 2016;15(10):1235-1237.
Sinclair R. There is no clear association between low serum ferritin and chronic diffuse telogen hair loss. Br J Dermatol 2002;147(5):982-4.
Ertug EY, Yilmaz RA. Reduced ferritin, folate, and vitamin B12 levels in female patients diagnosed with telogen effluvium. Int J Med Biochem 2018;1(3):111-114.
Maner BS, Moosavi L. Mean Corpuscular Volume. [Updated 2021 Jul 10]. In: StatPearls Treasure Island (FL): StatPearls Publishing; 2021.
Rasheed H, Mahgoub D, Hegazy R, El-Komy M, Abdel HR, Hamid MA, Hamdy E. Serum ferritin and vitamin d in female hair loss: do they play a role? Skin Pharmacol Physiol. 2013;26(2):101-7.
Seçkin HY, Bütün I, Baş Y, Takcı Z, Kalkan G. Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis. J Dermatolog Treat 2016;27:389-91.
Kim DS, Shin D, Kim TG, Kim SH, Kim DY, Kim SM, et al. Red blood cell distribution width as a useful indicator to predict systemic vasculitis in patients with cutaneous vasculitis. Rheumatol Int 2015;35:719-25.
Önmez A, Bilir E, Torun S. Akut Pankreatit Şiddeti ile Trombosit Lenfosit Oranı, Nötrofil Lenfosit Oranı, Eritrosit Dağılım Genişliği ve Ortalama Platelet Volümü Arasındaki İlişki. Konuralp Med J 2019;11(1):24-29.
Fava C, Cattazzo F, Hu ZD, Lippi G, Montagnana M. The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? Ann Transl Med. 2019;7(20):581.
Published
Issue
Section
License
Copyright (c) 2022 Saadet İbiş, Gülhan Aksoy Saraç, Turan Akdağ

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.

