Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial

Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial

Authors

  • Nasrin Saki Molecular Dermatology Research Center, Shiraz University of Medical Sciences & Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran
  • Raya Mokhtari Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran
  • Farnoosh Nozari Molecular Dermatology Research Center, Shiraz University of Medical Sciences & Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Keywords:

keloid, verapamil, triamcinolone, Vancouver Scar Scale, scar

Abstract

Background: Keloid management remains a challenging clinical problem despite numerous therapies reported until now. The efficacy of corticosteroids in the treatment of keloids has been well established. The most commonly used corticosteroid is intralesional triamcinolone. Sporadic reports on the use of intralesional verapamil suggest its efficacy.

Aim: Since there is not sufficient evidence to support the role of intralesional verapamil as an effective alternative modality, it was decided to undertake a randomized study to determine its efficacy as a treatment for keloids.

Methods: A randomized, single-blind, single-group comparison with 15 patients (30 scars) was carried out to compare the effects of intralesional triamcinolone with verapamil injections. Injections were scheduled every 3 weeks accompanied by cryotherapy until complete flattening of the scar or maximum 8 sessions, whichever came earlier. Scar evaluation at each stage was done by serial photographic records as well as by Vancouver scar scale. Statistical analysis was done by Wilcoxon and Mann-Whitney U tests using SPSS version 19.

Results: In both study groups there was a reduction in height and pliability at the end of the study. Better improvement in height and pliability was seen with triamcinolone in comparison with verapamil. However, a desired change in vascularity and pigmentation was not seen with either of the drugs.

Conclusion: Verapamilis not as effective as triamcinolonein the treatment of keloids.

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Published

2019-01-31

Issue

Section

Research

How to Cite

1.
Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial. Dermatol Pract Concept [Internet]. 2019 Jan. 31 [cited 2024 Mar. 29];9(1):4-9. Available from: https://www.dpcj.org/index.php/dpc/article/view/dermatol-pract-concept-articleid-dp0901a02